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Related Concept Videos

Infertility in Females01:28

Infertility in Females

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Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
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Infertility in Males01:23

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Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
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Cancer Survival Analysis01:21

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Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Spermatogenesis01:41

Spermatogenesis

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Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Response to: Letter to the editor-Fertility after cancer.

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Related Experiment Video

Updated: May 24, 2025

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives
08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

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Fertility after cancer.

Jaideep Malhotra1, Diksha Goswami1, Neharika Malhotra1

  • 1Rainbow IVF, Agra, India.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|March 5, 2025
PubMed
Summary
This summary is machine-generated.

Cancer treatments like chemotherapy and radiotherapy can lead to infertility. Fertility preservation options, such as cryopreservation, offer hope for future pregnancies after cancer treatment, despite associated risks.

Keywords:
cancerchemotherapycryopreservationembryofertilityoocyteradiotherapysemen

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Area of Science:

  • Oncology
  • Reproductive Medicine
  • Genetics

Background:

  • Cancer therapies, including chemotherapy and radiotherapy, can profoundly impact female fertility by affecting the ovaries and uterus.
  • When fertility preservation methods like cryopreservation are not utilized or available, alternative reproductive strategies are necessary.

Purpose of the Study:

  • To review the impact of cancer therapy on female fertility.
  • To outline available reproductive options for cancer patients.
  • To discuss the risks and considerations associated with fertility preservation and post-cancer pregnancy.

Main Methods:

  • Literature review of studies on cancer therapy's effects on fertility.
  • Analysis of reproductive options including spontaneous conception, donor gametes, adoption, surrogacy, and cryopreservation (oocyte, embryo, ovarian tissue).
  • Examination of risks related to fertility preservation procedures and pregnancies post-cancer cure.

Main Results:

  • Cryopreservation of gametes and tissues offers a chance for pregnancy after cancer treatment.
  • Fertility preservation in women carries risks, including surgical complications, ovarian hyperstimulation syndrome, and potential delays in cancer therapy.
  • Pregnancies after cancer treatment have increased risks such as premature labor, cesarean delivery, congenital anomalies, and disease transmission.

Conclusions:

  • Fertility preservation techniques provide crucial reproductive opportunities for cancer patients.
  • Careful consideration of risks is essential for both fertility preservation and post-cancer pregnancies.
  • Reimplantation of ovarian tissue requires careful evaluation to avoid the risk of malignant cell transfer.