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Updated: May 24, 2025
Author Spotlight: Non-Surgical Treatment of Melasma– Microneedling with Tranexamic Acid
Published on: January 19, 2024
Intravenous Tranexamic Acid in Rhinoplasty: A Randomized Controlled Trial
Elizabeth S Longino1, Nicole G Desisto1, Feyi Adegboye1
1Otolaryngology & Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Background:
Existing data on tranexamic acid (TXA) in rhinoplasty are mixed.
Objective:
Compare blood loss, edema, and bruising in patients undergoing septorhinoplasty with or without intravenous (IV) TXA, measured by estimated blood loss and photograph review of edema/ecchymosis.
Design:
Randomized controlled trial (NCT05774717).
Methods:
Patients undergoing open septorhinoplasty were eligible. Participants were randomized to receive 1 g IV TXA preoperatively or routine medications only. Intraoperative bleeding was measured using the Boezaart scale and sponge saturation. Patients rated periorbital edema/ecchymosis at 1 week. Photos were reviewed by a facial plastic surgeon to grade edema/ecchymosis.
Results:
There were 139 participants: 73 (53%) female, mean age of 42 ± 15 years, and 13% revision procedures. Sixty-nine (50%) received TXA. Boezaart scores were 2.25 and 2.41 (p = 0.3), and sponge scores were 0.76 and 0.84 (p = 0.4) in the TXA and control groups, respectively. Postoperative edema/ecchymosis were 1.15/1.19 out of 4 in the TXA group, and 0.97/1.05 in the control group. Surgeon-graded edema/ecchymosis were 1.78/1.76 (TXA) and 1.82/1.86 (control). There was no difference in epistaxis, pain, or appearance satisfaction.
Conclusions:
In this study, there was no difference in bleeding, edema, ecchymosis, or postoperative experience associated with TXA.
