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Updated: Jun 14, 2025
![An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F66708.jpg&w=3840&q=50)
An Automated Radiosynthesis of [68Ga]Ga-FAPI-46 for Routine Clinical Use
Published on: May 24, 2024
18 F-FDG PET/CT Identified Rectal Malignancy Earlier Than 68 Ga-FAPI PET/CT
1Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.
Abstract:
A 69-year-old man with esophageal cancer underwent dual-tracer PET/CT using 18 F-FDG and 68 Ga-FAPI during his treatment. At baseline, neither scan showed abnormal uptake in the rectum. Three months later, an interim 18 F-FDG PET/CT revealed focal uptake in the rectum, while the 68 Ga-FAPI PET/CT showed no abnormal findings. Seventeen months later, he received a third dual-tracer PET/CT for surveillance. Both 18 F-FDG and 68 Ga-FAPI PET/CT detected abnormal activity in the same area of the rectum . The lesion was later confirmed as adenocarcinoma by histopathology after surgery. Our case demonstrated the 18 F-FDG PET/CT could identify the rectal malignancy before 68 Ga-FAPI PET/CT.
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