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Updated: May 24, 2025

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Manganese-Promoted Electrochemical Imino-Pinacol Coupling to Access Vicinal Diamines
Weihao Cui1, Xiaolong Xu1, Cong Zhang1
1College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, China.
Abstract:
We herein introduce an electrochemical imino-pinacol coupling reaction to access the vicinal diamine scaffold. This green and convenient protocol employs in situ-generated imines as starting materials to deliver a broad range of diamine products under electroreductive conditions. Moreover, this protocol is also applicable to electrochemical pinacol coupling. Mechanistic investigation suggests that a Mn(III) additive is essential for promoting the SET reduction of the imine starting material and preventing the formation of the over-reduced amine side product.
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