[A case of metastatic renal cell carcinoma with complete remission achieved by interferon therapy]

A case of metastatic renal cell carcinoma in which complete remission was achieved using Interferon therapy is reported. A 67-year-old male was found to have extensive paraaortic lymph node metastasis while undergoing left nephrectomy following diagnosis of 1-renal cancer. Pathological diagnosis of the node was metastasis of clear cell type renal cell carcinoma. Interferon (Hu IFN-alpha 2: Sch 30500; Yamanouchi Pharmaceutical Co.) therapy was started 34 days after surgery. The Interferon was administered i.m. at a dose of 1 X 10(6) units per injection, 3 times a week, and was continued up to a total dose of 236 X 10(6) units. Response of the metastatic lymph nodes was examined using CT scan. Marked response was observed 4 weeks after starting the Interferon therapy, and complete disappearance of the tumors was obtained 5 months after Commencement of therapy. The duration of complete response has lasted 4 months. The toxic manifestations of the Interferon therapy were fever and loss of appetite.