Related Experiment Video
Updated: May 3, 2026
05:56
Scleral Cross-linking Using Riboflavin and Ultraviolet-A Radiation for Prevention of Axial Myopia in a Rabbit Model
Published on: April 3, 2016
8.8K
One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old
Jiangtao Lou1, Hailu Huang1, Yiyi Peng2
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Investigative Ophthalmology & Visual Science
|March 5, 2025
Summary
Younger rabbits (1-month-old) showed more significant extraocular muscle (EOM) remodeling after surgery than older rabbits (3-month-old). This suggests age influences EOM plasticity and potentially strabismus surgery outcomes.
Area of Science:
- Ophthalmology
- Muscle Biology
- Developmental Biology
Background:
- Extraocular muscles (EOMs) undergo remodeling after strabismus surgery.
- The impact of age on postoperative EOM remodeling is not fully understood.
- Understanding age-related differences is crucial for optimizing surgical outcomes.
Purpose of the Study:
- To investigate differences in postoperative extraocular muscle (EOM) remodeling between 1-month-old and 3-month-old rabbits.
Main Methods:
- Superior rectus (SR) muscles of rabbits underwent recession or resection surgery.
- Tissues were analyzed 1 and 4 weeks post-surgery for myosin heavy chain (MyHC) isoform expression, activated satellite cells (SCs), and centrally nucleated myofibers.
- Age-matched unoperated rabbits served as controls.
Main Results:
- One-month-old rabbits showed continuous decrease in fast 2X-MyHC and increase in embryonic MyHC post-surgery.
- Three-month-old rabbits exhibited transient changes in fast 2X-MyHC and embryonic MyHC, returning to baseline levels by 4 weeks.
- Activated satellite cells and centrally nucleated myofibers were more prevalent in 1-month-old rabbits postoperatively.
Conclusions:
- One-month-old rabbits demonstrate greater EOM plasticity and longer postoperative remodeling compared to 3-month-old rabbits.
- Age-dependent differences in EOM remodeling may influence strabismus surgery outcomes in pediatric patients.
Related Concept Videos
01:40Bone Remodeling
34.4K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.4K
01:29Bone Formation by Intramembranous Ossification
16.1K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
16.1K
01:09Changes in the Appendicular Skeleton with Age
3.2K
The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
3.2K
01:27Signs of Puberty
2.1K
Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
2.1K