Global Burden of the Key Components of Cardiovascular-Kidney-Metabolic Syndrome
Zhaomin Xie1, Chaolun Yu2, Qingmei Cui1
1Global Health Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Journal of the American Society of Nephrology : JASN
|March 5, 2025
Insights
Cardiovascular-kidney-metabolic (CKM) syndrome poses a growing global health challenge. This study quantifies its burden, revealing increasing DALYs driven by population growth and aging, with significant regional variations.
Area of Science:
- Global Health
- Epidemiology
- Metabolic Diseases
Background:
- Cardiovascular-kidney-metabolic (CKM) syndrome links metabolic diseases, chronic kidney disease (CKD), and cardiovascular diseases.
- It represents a significant and escalating global public health concern.
Purpose of the Study:
- To quantify the global burden of CKM syndrome and its key components.
- To analyze trends and project future burden through 2046.
Main Methods:
- Utilized data from the Global Burden of Disease 2019 study.
- Employed decomposition analysis for population growth, aging, and epidemiologic changes.
- Applied a NORDPRED model for future burden projections.
Main Results:
- Ischemic heart disease and stroke were major contributors to CKM burden in 2021.
- Middle sociodemographic index regions showed the largest burden, while lower SDI regions had higher age-standardized DALY rates.
- DALYs increased from 1990-2021 due to population growth and aging; diabetes and high body mass index showed increasing trends, while stroke, PAD, and IHD declined.
- Future projections indicate a continued increase in CKM syndrome burden through 2046.
Conclusions:
- The study underscores the substantial and increasing global burden of CKM syndrome.
- Findings highlight the need for targeted interventions and public health strategies to address this complex syndrome.
Abstract
No abstract available in PubMed .
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