Related Experiment Video
Updated: May 24, 2025
A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
Published on: November 6, 2015
Getting fit for hip and knee replacement: The Fit-Joints multimodal intervention for frail patients with
Chinenye Okpara1, Ahmed Negm2, Jonathan Derrick Adachi3
1Department of Health Research Methodology, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Background:
Older adults with frailty have high risk for poor postoperative outcomes.
Objective:
To evaluate the feasibility of a multimodal prehabilitation program in older adults with frailty awaiting hip or knee replacement.
Design:
Parallel two-arm randomized controlled pilot trial.
Participants And Setting:
Community-dwelling older adults with frailty awaiting joint replacement aged ≥60 years recruited from the Musculoskeletal Central Intake and Assessment Centre (MSK CIAC), Ontario.
Intervention:
Exercise, protein and vitamin D supplements, and medication review.
Measurement:
Feasibility was assessed based on predefined progression criteria for recruitment, retention, data completion and adherence to intervention components. Clinical outcomes including Oxford Knee and Hip Scores, frailty index, Short Physical Performance Battery and health-related quality of life were collected at baseline, 1-week preoperative, 6-weeks and 6-months postoperative and were evaluated using generalized linear mixed models for repeated measures.
Results:
A total of 69 participants were enrolled. Recruitment rate was 35 %. Participants' mean age was 74 (standard deviation (SD): 7.5); 51 % were prefrail and 36 % were frail. Participant retention was 81 %, and data completion was ≥80 %. Mean adherence to strength exercises was 4 days (95 % confidence interval (CI): 3-5 days/week), balance 3 days (95 % CI: 2-4 days/week), and flexibility 3 days (95 % CI: 3-4 days/week). Adherence to vitamin D intake was 82 % (95 % CI: 73-92 %), and medication review consultation completion was 86 % (95 % CI: 68-95 %). These outcomes met the target values for feasibility success. The Oxford Knee Score at 6-months postoperative 8.78 (95 % CI: 0.40-17.16) showed a clinically meaningful and statistically significant difference between treatment groups. There were also indications of clinically relevant changes for frailty and quality of life post-surgery.
Conclusion:
This trial provides strong evidence of feasibility and indications of improvements in postoperative clinical outcomes. Challenges to implementation and adherence were identified that can inform modifications to study design for future trials.
Trial Registration:
ClinicalTrials.gov NCT02885337. Registered August 31, 2016. https://classic.
Clinicaltrials:
gov/ct2/show/NCT02885337.
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