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Related Experiment Videos

Hydrogen breath test in schoolchildren.

A C Douwes, C Schaap, J M van der Klei-van Moorsel

    Archives of Disease in Childhood
    |April 1, 1985
    PubMed
    Summary

    A small percentage of healthy children (9.2%) had negative hydrogen breath tests, indicating colonic bacteria unable to produce hydrogen. This study determined the frequency of false-negative results in hydrogen breath tests.

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    Area of Science:

    • Gastroenterology
    • Microbiology
    • Pediatrics

    Background:

    • Hydrogen breath tests are common diagnostic tools.
    • Colonic bacteria can influence test results.
    • Understanding false negatives is crucial for accurate diagnosis.

    Purpose of the Study:

    • To determine the frequency of negative hydrogen breath tests in healthy children.
    • To assess the implications of these negative results for lactose malabsorption testing.
    • To investigate potential familial clustering of this phenomenon.

    Main Methods:

    • Oral lactulose challenge in 98 healthy Dutch schoolchildren.
    • Hydrogen breath test analysis.
    • Faecal incubation tests with various sugars.
    • Analysis of siblings and mothers.

    Main Results:

    • 9.2% of healthy children exhibited negative hydrogen breath tests.
    • The probability of a false-normal lactose breath test was calculated as 1:77.
    • No familial clustering was observed for this condition.
    • Faecal tests correlated with breath test results.

    Conclusions:

    • The frequency of false-negative hydrogen breath tests is higher than previously thought.
    • This does not diminish the hydrogen breath test's superiority over blood glucose tests.
    • Accurate interpretation of hydrogen breath tests requires consideration of colonic flora.

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