Whipple's disease in a patient with follicular lymphoma

Whipple's disease is a rare condition that can present with nonspecific constitutional symptoms that can mimic those of cancer diagnosis. A high index of suspicion as well as adequate testing are necessary in order to avoid delay in diagnosis and treatment of Whipple's disease. Herein, we describe a patient who presented with an initial diagnosis of follicular lymphoma which did not respond to chemotherapy, and who, after further workup, was diagnosed with Whipple's disease including gastrointestinal, central nervous system, and cardiac compromise.