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Updated: May 24, 2025
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Lipidomics and Transcriptomics in Neurological Diseases
Published on: March 18, 2022
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Transformative potentials, challenges and innovative solutions of lipidomics in multiple clinical applications
Malarvannan M1, Bhanu Teja Naik Sabavath1, Vyomika Gaddam1
1Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research (NIPER)-Kolkata, West Bengal, 700054, India.
Talanta
|March 5, 2025
Summary
Lipidomics advances biomarker discovery for diseases like Alzheimer's and diabetes. New analytical methods and sample preparation techniques improve lipid identification for personalized medicine and diagnostics.
Area of Science:
- Lipidomics
- Metabolomics
- Biomarker Discovery
Background:
- Lipidomics offers comprehensive insights into lipid profiles and their roles in health and disease.
- Advances in lipidomics are revolutionizing disease diagnosis, prognosis, and therapeutic monitoring.
- Lipidomics aids in discovering novel biomarkers with significant clinical applications.
Purpose of the Study:
- To review innovative developments in lipidomics analytical technologies and sample preparation.
- To highlight challenges and bioinformatic tools in lipidomics research.
- To emphasize the transformative potential of lipidomics in biomarker discovery for diverse clinical applications.
Main Methods:
- High-resolution mass spectrometry (HRMS)
- Ion mobility spectrometry (IMS)
- Supercritical Fluid Chromatography (SFC)
- Advanced sample preparation techniques
Main Results:
- Lipidomics has illuminated critical pathways in cardiovascular disorders, neurodegenerative conditions, metabolic syndromes, and cancers.
- Specific lipid classes like sphingolipids (SLs) and phospholipids (PLs) are linked to Alzheimer's disease and diabetes.
- Oxylipins and eicosanoids are emerging as important inflammatory biomarkers.
Conclusions:
- Lipidomics, supported by advanced analytical and preparation techniques, is crucial for biomarker discovery.
- Lipidomic profiles show promise in personalized medicine for patient stratification and tailored treatments.
- Continued innovation in lipidomics research will further enhance its clinical applications.
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