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Association between interleukin-6, suPAR, and hsCRP with subclinical left ventricular dysfunction in type 1 diabetes:

Hashmat Sayed Zohori Bahrami1, Peter Godsk Jørgensen2, Jens Dahlgaard Hove3

  • 1Department of Clinical and Translational Research, Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark; Department of Cardiology, Copenhagen University Hospital, Amager & Hvidovre, Kettegård Alle 30, 2650 Hvidovre, Denmark; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3b, 2200 Copenhagen, Denmark.

Diabetes Research and Clinical Practice
|March 5, 2025
PubMed

Insights

Chronic inflammation, measured by biomarkers like IL-6, suPAR, and hsCRP, is linked to subclinical left ventricular dysfunction in type 1 diabetes (T1D). These findings suggest inflammation may drive heart problems in T1D patients.

Area of Science:

  • Cardiology
  • Endocrinology
  • Immunology

Background:

  • Type 1 diabetes (T1D) is associated with an increased risk of cardiovascular complications.
  • Subclinical left ventricular dysfunction can precede overt heart failure in T1D.
  • Chronic inflammation is implicated in the pathogenesis of various diabetic complications.

Purpose of the Study:

  • To investigate the association between specific inflammatory biomarkers and subclinical left ventricular dysfunction in individuals with T1D.
  • To determine if biomarkers such as interleukin-6 (IL-6), soluble-urokinase-plasminogen-activator-receptor (suPAR), and high-sensitivity C-reactive-protein (hsCRP) correlate with echocardiographic measures of cardiac function.
  • To explore the combined effect of these inflammatory markers on left ventricular function.

Main Methods:

  • A cross-sectional study was conducted on 962 individuals with T1D and no known heart disease.
  • Blood levels of IL-6, suPAR, and hsCRP were measured and categorized based on upper quartiles.
  • Echocardiographic parameters, including E/e' (primary) and global longitudinal strain (GLS) (secondary), were assessed. Linear regression analysis was used, adjusting for clinical variables.

Main Results:

  • All examined inflammatory biomarkers (IL-6, suPAR, hsCRP) were independently associated with increased E/e' and decreased GLS.
  • Elevated levels of combined biomarkers showed stronger associations with left ventricular dysfunction.
  • Specifically, elevated IL-6 and suPAR were linked to significantly worse cardiac function, as were all three elevated biomarkers.

Conclusions:

  • Chronic inflammation, indicated by elevated IL-6, suPAR, and hsCRP, is independently associated with subclinical left ventricular dysfunction in T1D.
  • These inflammatory markers may play a significant role in the development of myocardial dysfunction in individuals with type 1 diabetes.
  • Targeting inflammation could be a potential strategy to prevent cardiac complications in T1D.
Abstract

Keywords:
BiomarkersDiabetes Mellitus, Type 1DiastoleHeart failureInflammation

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