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Epigenetics in autoimmune diseases: Unraveling the hidden regulators of immune dysregulation
Giacomo Bagni1, Edoardo Biancalana2, Emanuele Chiara2
1Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy; Department of Clinical and Biological Sciences, University of Turin, Turin, Italy.
Abstract:
Autoimmune diseases result from complex interactions between genetic and environmental factors. Recent advances in epigenetic research shed light on the intricate regulatory mechanisms that contribute to the development and progression of such conditions. The present review aims to explore the role of epigenetic modifications, including DNA methylation, histone modifications, and non-coding RNAs, in the context of autoimmune diseases. We discuss the current understanding of epigenetic alterations associated with various autoimmune disorders, their impact on immune cell function, and their potential as innovative therapeutic targets. Additionally, we highlight the main future directions in the field of epigenetics in autoimmunity.
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