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National cohort study on cardiometabolic index and incident stroke in middle-aged and older adults in China

HaiXia He1, DanDan Li2, LiangYing Liao1

  • 1The First Hospital of Hunan University of Chinese Medicine, Changsha, China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|March 5, 2025
PubMed

Insights

The Cardiometabolic Index (CMI) is linked to higher stroke risk in older Chinese adults. This marker can help predict and prevent strokes in public health initiatives.

Area of Science:

  • Cardiology
  • Metabolic Health
  • Public Health

Background:

  • The Cardiometabolic Index (CMI) integrates central obesity and lipid metabolism.
  • CMI is a marker for metabolic health, linked to diabetes and cardiovascular diseases.
  • CMI's role in stroke risk prediction is not well-established.

Purpose of the Study:

  • To investigate the association between CMI and stroke risk.
  • To assess CMI as a predictive tool for stroke in Chinese adults aged 45+.

Main Methods:

  • Analysis of data from the China Health and Retirement Longitudinal Study (CHARLS).
  • Participants categorized into CMI quartiles; stroke incidence as primary endpoint.
  • Cox proportional hazards models, Kaplan-Meier curves, and restricted cubic splines (RCS) used for analysis.

Main Results:

  • 7,821 participants followed for 7 years; 418 strokes observed.
  • Higher CMI significantly associated with increased stroke risk (HR=1.153, P=0.004).
  • RCS showed a non-linear increase in stroke risk with rising CMI (P=0.005).

Conclusions:

  • Elevated CMI correlates with increased stroke risk in middle-aged and older Chinese adults.
  • Integrating CMI into routine assessments may enhance early stroke prevention.
  • This approach can help manage the growing burden of cerebrovascular disease.

Keywords:
Cardiometabolic indexChina health and retirement longitudinal studyMetabolic healthNon-linear associationStroke

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