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B Cell Activation and Differentiation

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...

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Related Experiment Video

Updated: May 24, 2025

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Stem Cell-Derived Viral Ag-Specific T Lymphocytes Suppress HBV Replication in Mice

Published on: September 25, 2019

[Research progress on B cells in chronic hepatitis B].

L L Tang¹, R N Xu¹, F S Wang¹

¹Senior Department of Infection Disease, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China.

Zhonghua Gan Zang Bing Za Zhi = Zhonghua Ganzangbing Zazhi = Chinese Journal of Hepatology

|March 5, 2025

Summary

B cells are crucial for fighting hepatitis B virus (HBV). Chronic HBV infection shows abnormal B cell differentiation and impaired non-antibody functions, hindering viral clearance and suggesting new therapeutic targets.

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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells

Published on: June 5, 2020

Area of Science:

Immunology
Virology
Hepatology

Background:

B cells are vital for humoral immunity and hepatitis B virus (HBV) clearance.
Immune responses to HBV antigens reveal B cell antigenic heterogeneity during infection.

Purpose of the Study:

To elucidate the role and function of B cells in chronic hepatitis B (CHB) infection.
To provide a scientific basis for developing novel therapeutic strategies against CHB.

Main Methods:

Analysis of B cell differentiation and function in CHB patients.
Investigation of immunological responses to different HBV antigens.

Main Results:

Patients with CHB exhibit abnormal differentiation of hepatitis B surface antibody-specific B cells.
Hepatitis B core antibody-specific B cells remain relatively intact in CHB patients.
Defects in non-antibody-generating B cell functions contribute to persistent HBV infection.

Conclusions:

B cell dysfunction, particularly impaired non-antibody functions and abnormal differentiation, is implicated in persistent HBV infection.
Understanding these B cell defects offers insights for developing targeted immunotherapies for CHB.