[Course of serum alkaline phosphatase during treatment with isoniazid and rifampicin]

In a population of 132 tuberculous children coming from immigrant families, statistical analysis of data showed a significant increase in serum alkaline phosphatase levels. This phenomenon is more significant when several antibiotics are used (Isoniazid and Rifampicin) than when monotherapy is used (Isoniazid). These results demonstrate a high tendency to occult osteomalacia in tuberculous patients treated by tuberculostatic drugs.