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Association between cardiometabolic index and biological ageing among adults: a population-based study

Na Liu1,2, Shanshan Peng1, Kai Wei1

  • 1Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, China.

BMC Public Health
|March 5, 2025
PubMed

Insights

The cardiometabolic index (CMI) is linked to faster biological aging in US adults. Higher CMI indicates increased biological age acceleration, particularly in women and those with diabetes.

Area of Science:

  • Gerontology
  • Cardiovascular Health
  • Metabolic Health

Background:

  • Cardiovascular health (CVH) is intrinsically linked to the aging process.
  • Biological aging is a critical factor in age-related diseases.
  • The cardiometabolic index (CMI) is a novel indicator of cardiometabolic status.

Purpose of the Study:

  • To investigate the association between the cardiometabolic index (CMI) and biological aging.
  • To determine if CMI is an independent predictor of biological age acceleration (BioAgeAccel).

Main Methods:

  • Utilized cross-sectional data from the National Health and Nutrition Examination Survey (2011-2018).
  • Calculated biological age acceleration (BioAgeAccel) based on eight biomarkers.
  • Employed weighted multivariable regression, sensitivity, and smoothing curve analyses.

Main Results:

  • A positive correlation was observed between CMI and biological age in 4282 US adults (≥20 years).
  • Each unit increase in CMI correlated with a 1.16-year increase in BioAgeAccel.
  • The highest CMI quartile showed 2.49 years greater BioAgeAccel compared to the lowest quartile.
  • This association was more pronounced in females, individuals with diabetes, and those without hypertension.

Conclusions:

  • The cardiometabolic index (CMI) is positively associated with biological aging in US adults.
  • Findings suggest CMI may serve as a marker for accelerated aging.
  • Further prospective studies with larger cohorts are necessary for validation.
Abstract

Keywords:
Biological ageingCardiometabolic indexNHANES

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