SRC involves in lysosomal function and regulates ferroptosis in polycystic ovary syndrome

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Tianmei Wang1, Xin Chen2, Cong Li3

  • 1Department of Gynecology, First Affiliated Hospital of Chongqing Medical University, Yuzhong District, Chongqing, 400016, P.R. China.

Journal of Ovarian Research
|March 5, 2025
PubMed
Abstract

Insights

The study identifies SRC as a key gene linked to lysosomal function and ferroptosis in polycystic ovary syndrome (PCOS). Elevated SRC expression in PCOS ovarian tissues suggests it

Area of Science:

  • Genomics and Molecular Biology
  • Reproductive Endocrinology
  • Cellular Metabolism

Background:

  • Polycystic ovary syndrome (PCOS) pathogenesis remains unclear, necessitating research into its molecular mechanisms.
  • Identifying key molecular pathways is crucial for understanding and potentially treating PCOS.

Purpose of the Study:

  • To identify novel molecular mechanisms and potential biomarkers for PCOS.
  • To investigate the role of lysosomal function and ferroptosis in PCOS pathogenesis.

Main Methods:

  • Utilized the GSE34526 dataset for gene expression analysis.
  • Performed Gene Set Enrichment Analysis (GSEA), KEGG, and Gene Ontology (GO) analyses.
  • Constructed a Protein-Protein Interaction (PPI) network to identify core genes.
  • Validated SRC gene expression in a rat model of PCOS.

Main Results:

  • Lysosomal pathways were significantly enriched in PCOS granulosa cells.
  • Identified overlapping differentially expressed genes related to lysosomes and ferroptosis, including SRC.
  • SRC was a central gene in the ferroptosis-related PPI network.
  • SRC expression was significantly upregulated in hyperandrogenemic PCOS rat ovaries.

Conclusions:

  • SRC plays a role in lysosomal function and ferroptosis regulation in PCOS.
  • SRC is a potential therapeutic target for PCOS management.
Keywords:
FerroptosisHub genesLysosomePCOS

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