Colorectal cancer mortality in persons with severe mental illness: a scoping review with meta-analyses of observational studies
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View abstract on PubMed
Summary
This summary is machine-generated.Individuals with severe mental illnesses (SMI) face a 25% higher risk of colorectal cancer (CRC) mortality. Tailored approaches are crucial to address disparities and improve CRC outcomes for this population.
Area Of Science
- Oncology
- Psychiatry
- Public Health
Background
- Individuals with severe mental illnesses (SMI) exhibit lower participation in colorectal cancer (CRC) screening.
- They are diagnosed at later stages and receive less adequate treatment compared to the general population.
- The impact of these disparities on CRC outcomes for persons with SMI is not fully understood.
Purpose Of The Study
- To systematically review and quantify colorectal cancer (CRC) mortality rates in individuals with severe mental illnesses (SMI) compared to the general population.
- To identify and synthesize existing evidence on CRC outcomes for persons with SMI.
Main Methods
- A systematic scoping review was conducted following JBI and PRISMA guidelines.
- Searches were performed across four databases up to April 29th, 2024.
- Included studies provided CRC mortality estimates for adults with a diagnosed SMI; results were synthesized descriptively and via meta-analysis.
Main Results
- Twenty-four studies encompassing over 16.4 million individuals were analyzed.
- The majority of studies indicated higher CRC mortality among persons with SMI.
- Meta-analysis revealed a 25% increased risk of CRC mortality for persons with SMI (pooled HR 1.25; 95% CI 1.13-1.39).
Conclusions
- Consistent evidence demonstrates elevated CRC mortality in individuals with SMI.
- Persons with SMI represent a heterogeneous group requiring tailored interventions.
- Future initiatives should focus on mitigating stigma and discrimination to improve CRC outcomes.
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