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Cefoxitin concentration in wound fluid.

D H Bagley, L S Zachary, M C Robson

    Archives of Surgery (Chicago, Ill. : 1960)
    |June 1, 1985
    PubMed
    Summary
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    Cefoxitin sodium administered intravenously quickly reached high concentrations in surgical wound fluid, exceeding levels needed to inhibit most bacteria. Higher doses of cefoxitin led to greater wound fluid drug levels.

    Area of Science:

    • Pharmacology
    • Surgical Infection Prevention
    • Clinical Microbiology

    Background:

    • Surgical site infections (SSIs) are a significant concern in healthcare.
    • Optimizing antibiotic concentrations at the surgical site is crucial for preventing SSIs.
    • Cefoxitin is a commonly used cephalosporin antibiotic for surgical prophylaxis.

    Purpose of the Study:

    • To determine cefoxitin concentrations in human surgical wound fluid.
    • To assess if cefoxitin levels exceed the minimal inhibitory concentration (MIC) for susceptible pathogens.
    • To evaluate the impact of different cefoxitin dosages on wound fluid concentrations.

    Main Methods:

    • Intravenous administration of cefoxitin sodium (1g or 2g every six hours).
    • Collection of surgical wound fluid on the first postoperative day.

    Related Experiment Videos

  • Measurement of cefoxitin concentrations in wound fluid and serum.

    • Main Results:

    • Rapidly achieved wound-fluid cefoxitin concentrations exceeded the MIC for most susceptible organisms.
    • Wound-fluid cefoxitin concentrations surpassed serum concentrations by three hours post-administration.
    • Higher cefoxitin dosages (2g) resulted in significantly higher wound-fluid drug levels.

    Conclusions:

    • Intravenous cefoxitin sodium effectively achieves therapeutic concentrations in surgical wound fluid.
    • The 2g dosage regimen provides superior cefoxitin levels in wound fluid compared to the 1g regimen.
    • Cefoxitin's pharmacokinetic profile supports its use in preventing surgical site infections.