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Updated: May 24, 2025
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Gold(I)-catalyzed tandem cyclization/peroxidation of 2-alkynyl-1-carbonylbenzenes with TBHP
Lang Chen1, Qibo Ni1, Yan Zhou1
1State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China. ykuiliu@zjut.edu.cn.
Abstract:
A gold(I)-catalyzed tandem cyclization/peroxidation of 2-alkynyl-1-carbonylbenzenes with tert-butyl hydroperoxide (TBHP) has been successfully developed to access 1-peroxidized 1H-isochromene derivatives in moderate to good yields. The use of one of the resultant 1-peroxidized 1H-isochromenes (3a) for the construction of phenyl(8-phenylbicyclo[4.2.0]octa-1(6),2,4,7-tetraen-7-yl)methanone (4), phenyl(3-phenyl-1,3-dihydroisobenzofuran-1-yl)methanone (5) and 2-(2-benzoylphenyl)-1-phenylethan-1-one (6) has also been investigated, respectively.
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