Related Experiment Video
Updated: May 24, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
38.7K
Increased Risk of Dermatomyositis in Patients with Psoriasis: A Retrospective Cohort Study
Miao Chen1, Na Tian1, Ran Cui1
1Department of Rheumatology and Immunology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
Immunotargets and Therapy
|March 6, 2025
Summary
Patients with psoriasis face an increased risk of developing dermatomyositis. This risk is particularly elevated in those with psoriatic arthritis or treated with interleukin-17 inhibitors.
Area of Science:
- Dermatology
- Rheumatology
- Epidemiology
Background:
- Psoriasis is a chronic inflammatory condition.
- Dermatomyositis is an idiopathic inflammatory myopathy.
- The association between psoriasis and dermatomyositis requires further investigation.
Purpose of the Study:
- To investigate the risk of dermatomyositis in patients with psoriasis.
- To compare dermatomyositis incidence between psoriasis patients and a matched non-psoriasis cohort.
Main Methods:
- Utilized the TriNetX database (2002-2022) including individuals aged ≥20 years.
- Employed propensity score matching (PSM) for 1:1 cohort comparison.
- Applied Kaplan-Meier curves and Cox proportional hazard models for risk assessment.
Main Results:
- Patients with psoriasis showed a significantly higher risk of dermatomyositis (HR: 2.41).
- Psoriatic arthritis patients had an increased incidence (HR: 1.73).
- Interleukin-17 inhibitor (IL-17i) treated patients exhibited a markedly higher risk (HR: 5.79).
Conclusions:
- Psoriasis is associated with an elevated risk of dermatomyositis.
- Psoriatic arthritis and IL-17i treatment further increase this risk.
- Findings highlight the need for vigilance in monitoring dermatomyositis in psoriasis patients.
Related Concept Videos
01:23Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K
01:24T Cell Types and Functions
756
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
756
01:27Psychoneuroimmunology: Cardiovascular Disease
23
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
23
01:26Factors Affecting the Risk of Infection
10.7K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
10.7K
01:29Pulmonary Tuberculosis I
215
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
215
01:20The JAK-STAT Signaling Pathway
8.6K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
8.6K