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Updated: May 24, 2025
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Association between systemic immune-inflammation index and central obesity in pediatric populations: a
Qian Zhang1,2, Bingxuan Kong2, Zhiyu Zhou2
1Department of Child and Adolescent Chronic Disease Prevention and Control, Shenzhen Center for Chronic Disease Control, Shenzhen, Guangdong, China.
Insights
The systemic immune inflammation index (SII) is linked to increased central obesity risk in children. Higher SII levels correlate with a greater likelihood of developing childhood obesity, suggesting its potential as an early detection marker.
Area of Science:
- Pediatric Endocrinology
- Immunology
- Public Health
Background:
- Central obesity in children is a major public health issue linked to metabolic and cardiovascular diseases.
- The systemic immune inflammation index (SII) is associated with obesity-related chronic inflammation.
- The relationship between SII and central obesity in pediatric populations requires further investigation.
Purpose of the Study:
- To investigate the association between SII and central obesity in children.
- To evaluate SII's potential as a predictor for central obesity.
- To explore early prevention strategies for childhood obesity using SII.
Main Methods:
- Utilized waist-to-height ratio (WHtR), subcutaneous fat, and visceral fat as obesity indicators.
- Defined central obesity using WHtR (cutoff value of 0.46).
- Employed cross-sectional (n=4,730) and prospective (n=1,425) study designs with logistic and Poisson regression models.
Main Results:
- Cross-sectionally, the highest quartile of SII showed a significantly higher risk of central obesity (OR=3.07).
- Subgroup analyses confirmed the association between elevated SII and central obesity.
- Longitudinally, the highest SII quartile predicted an increased risk of developing central obesity (RR=1.83).
Conclusions:
- Elevated SII levels are significantly associated with central obesity in children.
- SII may serve as a valuable predictive marker for identifying children at risk of central obesity.
- Early monitoring of SII could aid in the prevention of childhood obesity and its associated health complications.
Background:
Central obesity in children represents a significant public health concern due to its strong association with an elevated risk of metabolic and cardiovascular disorders. The systemic immune inflammation index (SII) has been implicated in the pathophysiology of obesity-related chronic inflammation. Despite its potential relevance, the specific relationship between central obesity and SII in the pediatric population remains insufficiently explored. The objective of this study was to examine the relationship between SII and central obesity, with a particular focus on the potential of SII as a predictor of central obesity and a means of preventing obesity at an early stage of life.
Methods:
Waist-to-height ratio (WHtR), subcutaneous fat, and visceral fat were employed as obesity proxies. Central obesity was defined according to WHtR with a cutoff value of 0.46. The implications of SII on central obesity were examined in a sample of 4,730 individuals in 2021 and validated through a prospective study involving 1,425 subjects in 2023. Cross-sectional associations between SII and central obesity were examined using binomial logistic regression models and generalized linear models. The restricted cubic spline regression was used to explore the non-linear relationship between SII and obesity indicators. In a prospective study, we employed a modified Poisson regression model to investigate the potential causal relationship between SII and central obesity.
Results:
Cross-sectionally, adolescents in the highest quartile of SII levels exhibited the greatest risk for central obesity(OR=3.07, 95% CI:2.45~3.87) when compared to those in the lowest quartile. Subgroup analyses showed that higher SII was associated with central obesity. Longitudinally, individuals in the highest SII quartile were found to have the highest risk of developing central obesity (RR=1.83, 95% CI:1.18~2.83) over time.
