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Updated: Jul 1, 2026
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A Standardized Method for the Analysis of Liver Sinusoidal Endothelial Cells and Their Fenestrations by Scanning Electron Microscopy
Published on: April 30, 2015
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Porto Sinusoidal Vascular Disorder: A Case Report
Naima Mukhtar Abdullahi1, Mohammed A M Ahmed1, Mohamed Abdulahi Yusuf2,3
1Department of Medicine, Faculty of Medicine and Surgery, Mogadishu University, Mogadishu, Somalia.
International Medical Case Reports Journal
|March 6, 2025
Summary
Porto sinusoidal vascular disease (PSVD) is a rare liver condition causing high portal vein pressure. This case highlights diagnostic challenges and the need for ongoing management of PSVD complications.
Area of Science:
- Hepatology
- Vascular Medicine
- Gastroenterology
Background:
- Porto sinusoidal vascular disease (PSVD) is an uncommon vascular disorder characterized by elevated portal venous pressure.
- The underlying pathogenicity of PSVD remains poorly understood, lacking clear links to cirrhosis or other common liver pathologies.
Observation:
- A rare case of PSVD presented with recurrent hematemesis and melena.
- Endoscopic evaluation revealed esophageal varices, but the cause of portal hypertension was unidentified despite extensive diagnostic workup including MRI, liver biopsy, and sonography.
Findings:
- The patient underwent band ligation and received medical management including beta-blockers and proton pump inhibitors.
- Despite symptomatic treatment, the patient developed pancytopenia secondary to splenomegaly, indicating persistent complications.
Implications:
- This case underscores the diagnostic complexities associated with PSVD.
- Effective management of PSVD requires close monitoring and follow-up due to potential complications like splenomegaly and pancytopenia.
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