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Prognostic Importance of Panimmune-Inflammation Value and PILE Scores in Non-Metastatic Luminal A Breast Cancer

  • 0Sivas Cumhuriyet University Faculty of Medicine, Department of Medical Oncology, Sivas, Turkey.
Breast Care +

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March 6, 2025

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March 6, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

The pan-immune-inflammation value (PIV) is a significant independent prognostic factor for survival in non-metastatic luminal A breast cancer patients. Lower PIV scores correlate with better overall survival and disease-free survival.

Area Of Science

  • Oncology
  • Immunology
  • Biomarkers

Background

  • Luminal A breast cancer is an important subtype with distinct prognostic factors.
  • Assessing prognostic significance of inflammation-based scores is crucial for treatment stratification.

Purpose Of The Study

  • To evaluate the prognostic significance of the pan-immune-inflammation value (PIV) and the PILE score in non-metastatic luminal A breast cancer.
  • To determine if PIV and PILE are independent prognostic factors for overall survival (OS) and disease-free survival (DFS).

Main Methods

  • Retrospective analysis of 293 non-metastatic luminal A breast cancer patients.
  • PIV calculated from neutrophil, platelet, monocyte, and lymphocyte counts.
  • PILE score derived from PIV, lactate dehydrogenase (LDH), and ECOG Performance Status (ECOG PS).

Main Results

  • Patients with low PIV and low PILE scores demonstrated significantly better OS and DFS.
  • PIV and PILE were significant prognostic factors for OS and DFS.
  • PIV emerged as an independent prognostic factor for OS and DFS (p=0.029 for OS, p=0.044 for DFS).

Conclusions

  • Lower PIV and PILE scores are associated with improved survival outcomes in non-metastatic luminal A breast cancer.
  • PIV is an independent prognostic factor, offering valuable information for survival prediction in this patient group.

Keywords: