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Updated: May 24, 2025
08:18
Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
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Metabolic reprogramming in cancer and senescence
Yuzhu Zhang1, Jiaxi Tang1, Can Jiang1
1Department of Pathology Xiangya Hospital School of Basic Medical Sciences Central South University Changsha China.
Medcomm
|March 6, 2025
Summary
Aging and cancer share links through nutrient sensing and metabolic changes. This review explores how cellular senescence impacts tumor growth, discusses interventions, and suggests dietary habits to combat aging and potentially cancer.
Area of Science:
- Gerontology and Oncology
- Metabolic Regulation in Aging and Cancer
Background:
- Global cancer incidence is rising, linked to an aging population.
- Cancer incidence and mortality increase with age.
- Dysregulated nutrient sensing in aging parallels tumor metabolic reprogramming, but the relationship is unclear.
Purpose of the Study:
- To comprehensively analyze the relationship between senescence and tumor metabolic reprogramming.
- To reveal the impact of key senescence factors on tumorigenesis.
- To summarize interventions targeting nutrient sensing and senescence in cancer treatment.
Main Methods:
- Literature review and analysis of existing research.
- Examination of key factors in cellular senescence and their role in cancer.
- Summary of current nanodelivery strategies for senescence-targeting cancer therapies.
Main Results:
- Aging significantly influences cancer incidence and mortality.
- Cellular senescence and metabolic reprogramming are interconnected in cancer development.
- Nutrient sensing pathways are critical in both aging and cancer.
Conclusions:
- Understanding the aging-metabolism link offers new avenues for cancer treatment.
- Targeting senescence and nutrient sensing pathways shows therapeutic potential.
- Dietary habits can influence aging and potentially impact cancer risk.
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