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Acute Typhlitis in a Patient with Common Variable Immunodeficiency
Kwame Dapaah-Afriyie1, Matthew Cannavo2, Vijairam Selvaraj1
1Division of Hospital Medicine The Miriam Hospital, Warren Alpert Medical School of Brown University.
The Brown Journal of Hospital Medicine
|March 6, 2025
Summary
Typhlitis, also known as neutropenic enterocolitis, is an intestinal inflammation affecting immunocompromised patients. This case study details an immunocompromised individual diagnosed with acute typhlitis, highlighting the condition
Area of Science:
- Gastroenterology
- Oncology
- Immunology
Background:
- Typhlitis, or neutropenic enterocolitis, is a serious gastrointestinal complication.
- It is characterized by inflammation and edema of the cecum, ascending colon, and terminal ileum.
- Incidence rates range from 3.5% to 5.3% in at-risk populations.
Observation:
- This report describes an immunocompromised individual presenting with abdominal pain.
- The patient was diagnosed with acute typhlitis.
Findings:
- Resolution of typhlitis typically correlates with the recovery of neutrophil counts.
- The case highlights the clinical presentation of typhlitis in an immunocompromised patient.
Implications:
- Understanding typhlitis is crucial for managing complications in immunocompromised patients.
- Early diagnosis and management can improve patient outcomes.
- Further research into preventative strategies and treatment protocols is warranted.
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