Related Experiment Video
Updated: May 5, 2026
05:23
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
18.9K
Update in Hyperferritinemic Syndromes: Recognition and Management - A Scoping Review.
Athanasios Vassilopoulos1, Winston McCormick2, Alisha Lakhani3
1Division of Infectious Diseases, Department of Medicine Warren Alpert Medical School at Brown University; Co-first author.
The Brown Journal of Hospital Medicine
|March 6, 2025
Summary
Elevated serum ferritin indicates macrophage activation and signals higher mortality risk. This review covers hyperferritinemic syndromes like HLH and MAS, crucial for timely diagnosis and better patient outcomes.
Area of Science:
- Internal Medicine
- Immunology
- Critical Care Medicine
Background:
- Elevated serum ferritin is a key indicator of macrophage activation.
- Hyperferritinemic syndromes, including HLH, MAS, CAPS, septic shock, AOSD, and MIS-C/A, are linked to severe inflammation and increased mortality.
- These conditions necessitate prompt recognition and management.
Purpose of the Study:
- To conduct a scoping review of the literature.
- To identify and summarize the key features of various hyperferritinemic syndromes.
Main Methods:
- Scoping review of existing literature.
Main Results:
- The review synthesizes information on the defining characteristics of these rare, severe inflammatory disorders.
- Key features contributing to diagnosis and management are highlighted.
Conclusions:
- Hyperferritinemic syndromes represent a spectrum of critical conditions.
- Understanding their shared and distinct features is vital for improving patient outcomes through early intervention.
Keywords:
adult-onset Still’s Diseasecatastrophic antiphospholipid syndromehemophagocytic lymphohistiocytosishyperferritinemicmacrophage activation syndromemulti- inflammatory syndromeseptic shockMore Related Videos
Related Concept Videos
01:22Lysosomal Hydrolases
3.7K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.7K
01:21Smooth Endoplasmic Reticulum
5.6K
Smooth endoplasmic reticulum or smooth ER is a sub-organelle with specialized functions in animal cells and plant cells. It is often associated with the tubule morphology of the endoplasmic reticulum.
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
The ER provides optimal conditions for synthesizing steroid hormones and lipids, such as phospholipids and triglycerides. Traditionally, lipid metabolism was considered to be a smooth ER function. However, there is no direct evidence to prove that rough ER is completely excluded from lipid...
5.6K
01:26Diseases of the Liver and Gallbladder
410
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
410
01:28Pleural Effusion II: Symptoms and Management
146
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
146
01:29Chronic Pancreatitis II: Collaborative Care
56
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
56