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Hypergravity induced prolactin surge in female rats.

E Megory, J Oyama

Aviation, Space, and Environmental Medicine

|May 1, 1985

Summary

Hypergravity exposure in female rats can trigger a prolactin surge, but only with specific timing and duration. Male rats did not show similar prolactin level changes under hypergravity conditions.

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Area of Science:

Endocrinology
Gravitational Biology
Reproductive Science

Background:

Previous studies indicated acute hypergravity (HG) induces prolonged diestrous in rats, reversible with continuous HG exposure.
Bromocriptine was identified as a preventive agent against HG-induced prolonged diestrous.

Purpose of the Study:

To investigate the specific conditions of hypergravity exposure that elicit a prolactin surge in female rats.
To determine if male rats exhibit similar prolactin responses to hypergravity stimulation.

Main Methods:

Female rats were exposed to 3.14 G for 20 hours (D-1 1200 h to D-2 0800 h).
Prolactin levels were measured at D-2 1600 h.
Control exposures included shorter durations (8 h) or different timing (19 h: D-1 0700 h to D-2 0200 h).
Male rats underwent similar HG exposure protocols.

Main Results:

A significant prolactin surge was observed in female rats following 20 hours of HG exposure.
Shorter or differently timed HG exposures failed to induce a prolactin surge in females.
HG exposure did not significantly alter prolactin levels in male rats.

Conclusions:

Specific duration and timing of hypergravity exposure are critical for inducing prolactin surges in female rats.
The hypothalamus may exhibit differential responses to HG stimulation between male and female rats.

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