Preliminary quantitative analysis of renal sinus fat dysfunction in T2DM patients using MRI fat fraction and R2*...

Area of Science:

• Radiology
• Medical Imaging
• Endocrinology

Background:

• Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder.
• Renal sinus fat (RSF) plays a role in metabolic health.
• Assessing RSF dysfunction could offer new insights into T2DM pathogenesis.

Purpose of the Study:

• To quantitatively analyze renal sinus fat (RSF) dysfunction in type 2 diabetes mellitus (T2DM) patients.
• Utilize magnetic resonance imaging (MRI) fat fraction (FF) and R2* mapping for assessment.
• Determine the association between RSF characteristics and T2DM.

Main Methods:

• 186 inpatients (38 T2DM, 148 non-T2DM) underwent 1.5 T abdominal MRI.
• Measured RSF volume, fat fraction (FF), and R2* values.
• Logistic regression and ROC curve analysis were used to assess associations and diagnostic performance.

Main Results:

• Mean RSF FF and R2* were significantly correlated with T2DM.
• Mean RSF FF was an independent risk factor for T2DM (OR: 1.231).
• AUC for RSF FF was 0.701, and for R2* was 0.616; combined AUC was 0.729.

Conclusions:

• Mean RSF FF is an independent predictor of T2DM.
• RSF dysfunction, indicated by adipocyte hypertrophy and altered iron deposition/hypoxia, is linked to T2DM.
• MRI-based RSF FF and R2* mapping show potential for T2DM diagnosis.