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Related Experiment Video

Updated: May 24, 2025

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
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[Choroidal neovascularization associated with choroidal nevi].

S A Smolin1, A S Stoyukhina1

  • 1Krasnov Research Institute of Eye Diseases, Moscow, Russia.

Vestnik Oftalmologii
|March 6, 2025
PubMed
Summary

Choroidal neovascularization (CNV) linked to choroidal nevi is a key concern in fundus diseases. This review covers CNV pathogenesis, diagnosis with OCT/OCT-A, and treatment strategies for pigmented lesions.

Keywords:
antiangiogenic therapychoroidal neovascularizationchoroidal nevusoptical coherence tomographyoptical coherence tomography angiography

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Area of Science:

  • Ophthalmology
  • Medical research
  • Angiogenesis

Background:

  • Choroidal neovascularization (CNV) is a significant pathological process in various fundus diseases.
  • Choroidal nevi are pigmented lesions that can be associated with CNV development.

Purpose of the Study:

  • To review the pathogenesis of CNV in choroidal nevi.
  • To examine diagnostic modalities and disease activity criteria.
  • To discuss differential diagnosis and treatment approaches.

Main Methods:

  • Review of existing literature on CNV and choroidal nevi.
  • Analysis of diagnostic techniques including optical coherence tomography (OCT) and OCT angiography (OCT-A).
  • Evaluation of treatment outcomes with antiangiogenic agents.

Main Results:

  • CNV associated with choroidal nevi presents unique pathogenetic and diagnostic challenges.
  • OCT and OCT-A are crucial for assessing disease activity and guiding treatment.
  • Differential diagnosis from conditions like age-related macular degeneration and melanoma is essential.

Conclusions:

  • Understanding CNV pathogenesis in choroidal nevi is vital for accurate diagnosis and management.
  • Modern imaging techniques enhance the assessment of disease activity.
  • Antiangiogenic therapy shows promise but requires careful consideration for pigmented lesions.