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Comorbidities and multimorbidity in asthma.

Diego J Maselli1, Jesse Sherratt1,2, Sandra G Adams1,2

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Managing asthma comorbidities like allergic rhinitis and obesity is crucial. Treating these conditions improves asthma control, quality of life, and reduces healthcare use, especially in severe or uncontrolled asthma cases.

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Area of Science:

  • Pulmonology and Respiratory Medicine
  • Clinical Medicine

Background:

  • Asthma management is complex, often influenced by co-existing medical conditions.
  • Comorbidities significantly impact asthma control, patient quality of life, and healthcare resource utilization.

Purpose of the Study:

  • To elucidate the associations between asthma and its common comorbidities.
  • To review current evidence on managing asthma in the presence of these comorbid conditions.

Main Methods:

  • Literature review of recent evidence on asthma comorbidities.
  • Analysis of management strategies for asthma with co-existing conditions.

Main Results:

  • Key comorbidities include allergic rhinitis, chronic rhinosinusitis, GERD, obesity, COPD, bronchiectasis, anxiety, and depression.
  • These conditions are linked to poorer asthma outcomes; their management improves asthma control.
  • Biologics show efficacy in asthma with CRS-NP and COPD; weight loss aids control; mental health conditions are often overlooked.

Conclusions:

  • Comorbidities are critical in diagnosing and treating asthma, particularly severe or uncontrolled cases.
  • Addressing comorbidities enhances quality of life, asthma control, and reduces healthcare utilization.
  • Integrated management of asthma and its comorbidities leads to improved patient outcomes.