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Label-free Isolation and Enrichment of Cells Through Contactless Dielectrophoresis
Published on: September 3, 2013
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Dielectrophoresis Tutorial: Inspired by Hatfield's 1924 Patent and Boltzmann's Theory and Experiments of 1874
1School of Engineering, Institute for Integrated Micro and Nanosystems, University of Edinburgh, Edinburgh, UK.
Electrophoresis
|March 6, 2025
Summary
Henry Stafford Hatfield
Area of Science:
- Physics
- Electrical Engineering
- Materials Science
Background:
- The first patent for dielectrophoresis (DEP) was granted in 1924.
- Hatfield's patent laid the groundwork for modern particle separation techniques using DEP.
- His work was informed by Boltzmann's studies on ponderomotive forces.
Purpose of the Study:
- To explore the foundational principles of dielectrophoresis (DEP).
- To connect historical DEP theory and practice to contemporary applications.
- To provide a tutorial for those new to DEP, drawing from Hatfield's patent and Boltzmann's work.
Main Methods:
- Analysis of Henry Stafford Hatfield's 1924 US patent on dielectrophoresis.
- Review of Hatfield's retrieved Ph.D. thesis from the University of London.
- Examination of Boltzmann's theoretical and experimental studies on ponderomotive forces.
Main Results:
- Hatfield's patent detailed novel sample preparation and electrode geometry for particle separation.
- Hatfield's thesis applied DEP to separate impurities from mineral ore.
- Boltzmann's work provided early theoretical underpinnings for the ponderomotive force in DEP.
Conclusions:
- Hatfield's patent and thesis, combined with Boltzmann's research, form a basis for understanding DEP.
- This historical perspective offers valuable insights for current DEP practitioners lacking formal physics training.
- The study highlights the enduring relevance of early 20th-century work in dielectrophoresis.
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