Visible Light-Mediated Selective Synthesis of β-Amino Sulfide Scaffolds via Dual Role of N-Iodosuccinimide
Organic Letters
|March 6, 2025
Abstract:
The synthesis of β-amino sulfides is significant in organic chemistry. However, challenges such as achieving regioselectivity and the limited availability of starting materials remain unresolved. In this study, we present a visible light-mediated method for the selective synthesis of β-amino sulfide scaffolds. Remarkably, two distinct types of β-amino sulfides were selectively synthesized through the dual role of N-iodosuccinimide, which functions as either a reactant or an activator in the construction of the target scaffolds.
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