Related Experiment Video
Updated: May 24, 2025
Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
Published on: May 3, 2018
Blood Pressure Time in Target Range Within 24 Hours and Cardiovascular Diseases and Mortality: Perspectives From a
Xue Tian1, Yijun Zhang1, Shuohua Chen2
1Department of Epidemiology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Clinical Epidemiology and Clinical Trials, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
Insights
Maintaining systolic blood pressure (SBP) within the target range (110-140 mm Hg) is linked to reduced cardiovascular disease (CVD) and mortality risks. Higher SBP time in target range (TTR) demonstrates a protective effect in real-world settings.
Area of Science:
- Cardiology
- Public Health
- Hypertension Management
Background:
- Ambulatory blood pressure monitoring (ABPM) provides crucial insights into blood pressure (BP) variability and control.
- Time in target range (TTR) is an emerging metric for assessing BP control and its clinical implications.
- Real-world data are essential for understanding the effectiveness of BP management strategies in diverse populations.
Purpose of the Study:
- To investigate the association between 24-hour, daytime, and nighttime systolic blood pressure (SBP) time in target range (TTR) and the risk of cardiovascular disease (CVD) and mortality.
- To evaluate the clinical utility of SBP TTR as a predictor of adverse cardiovascular outcomes in a real-world setting.
Main Methods:
- Utilized data from the Kailuan study, a large-scale, real-world cohort.
- Calculated SBP TTR using linear interpolation with a target range of 110 to 140 mm Hg.
- Employed Cox regression models to analyze the association between SBP TTR and CVD/mortality events after multivariable adjustment.
Main Results:
- Higher 24-hour SBP TTR was associated with significantly lower risks of CVD (HR, 0.89; P=.008) and all-cause mortality (HR, 0.89; P=.01).
- Increased daytime SBP TTR showed a strong association with reduced CVD risk (HR, 0.86; P=.005) and mortality (HR, 0.87; P=.003).
- Nighttime SBP TTR did not demonstrate statistically significant associations with the studied outcomes.
Conclusions:
- Higher SBP TTR, particularly during daytime, is a significant predictor of reduced CVD and mortality risk in Chinese adults.
- Achieving and maintaining SBP within the 110-140 mm Hg range over time represents a potentially effective strategy for cardiovascular disease prevention.
Objective:
To investigate the association of 24-hour, daytime, and nighttime ambulatory systolic blood pressure (SBP) time in target range (TTR) with the risk of cardiovascular disease (CVD) and mortality in real-world settings.
Patients And Methods:
Data were obtained from the Kailuan study. Systolic blood pressure TTR was calculated using linear interpolation, with 110 to 140 mm Hg as the target range. Cox regressions were performed to assess the associations of SBP TTR with outcomes.
Results:
Among 5099 participants in this analysis, 396 cases of CVD (7.77%) and 490 cases of all-cause mortality (9.61%) occurred during a median follow-up of 6.96 years. After multivariable adjustment, each 1-SD increment in 24-hour SBP TTR was associated with an 11% lower risk of CVD (hazard ratio [HR], 0.89; 95% CI, 0.79 to 0.99; P=.008) and all-cause mortality (HR, 0.89; 95% CI, 0.81 to 0.98; P=.01). Consistently, each 1-SD increment in daytime SBP TTR was associated with 14% lower risk of CVD (HR, 0.86; 95% CI, 0.78 to 0.95; P=.005) and 13% lower risk of all-cause mortality (HR, 0.87; 95% CI, 0.79 to 0.95; P=.003). However, the associations for nighttime SBP TTR did not reach statistically significant levels.
Conclusion:
Higher SBP TTR was associated with lower risk of CVD and mortality among Chinese adults in real-world settings. Efforts to attain SBP within 110 to 140 mm Hg over time may be an effective strategy to prevent CVD.
More Related Videos
Related Concept Videos
01:25Errors occurring during blood pressure monitoring
Several factors...
01:28Factors affecting Blood pressure
Physiological Factors:
01:15Assessment of blood pressure in brachial artery(one-step method)
Prepare for the Procedure:
01:17Measurement of Blood Pressure
01:18Hypertension and Regulation of Blood Pressure
01:28Special considerations while measuring blood pressure
Monitoring Both Arms:
Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.