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Dermabond Prineo: a systematic review and meta-analysis.
Shreya Kulkarni1,2, Matthew Goodbun1,3, Mohammed Chowdhury1,4
1Department of Vascular Surgery, Norfolk & Norwich University Hospital, Norwich, UK.
Journal of Wound Care
|March 6, 2025
Summary
Dermabond Prineo, a skin adhesive with a polyester mesh, significantly reduces surgical wound infection rates and delayed healing compared to traditional methods. It also offers improved cosmetic outcomes and faster application times.
Area of Science:
- Surgical Innovation
- Wound Management
- Medical Devices
Background:
- Dermabond Prineo combines a skin adhesive with a polyester mesh for surgical wound closure.
- It aims to reinforce wounds, equalize tension, reduce closure time, and improve healing.
- Conventional methods include sutures, staples, and other adhesives.
Purpose of the Study:
- To systematically review and assess published data on Dermabond Prineo.
- To compare infection rates, delayed wound healing, cosmetic appearance, and application time against conventional techniques.
- To evaluate Dermabond Prineo's efficacy across various surgical procedures.
Main Methods:
- A comprehensive literature search was conducted following PRISMA guidelines.
- Primary outcome: incidence of wound infection; Secondary outcomes: allergic reactions, application time.
- 19 studies were eligible for qualitative synthesis, and 12 for meta-analysis.
Main Results:
- Dermabond Prineo demonstrated a statistically significant reduction in wound infection rates (1.51% vs. 2.13%).
- A significant reduction in delayed wound healing was observed (0.99% vs. 1.79%).
- Improved cosmetic results and reduced application time were noted compared to sutures and traditional methods.
Conclusions:
- Dermabond Prineo is associated with lower wound infection rates and reduced delayed wound healing.
- The device offers potential benefits in cosmetic outcomes and application efficiency.
- Further real-world studies are needed to confirm cost-effectiveness.
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