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Related Experiment Videos

Polymicrobial bacteremia.

G A Roselle, C Watanakunakorn

    JAMA
    |November 30, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Polymicrobial bacteremia, involving multiple bacteria, occurred in 6% of blood cultures. Appropriate antimicrobial therapy significantly improved patient survival in this condition.

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    Area of Science:

    • Clinical Microbiology
    • Infectious Diseases
    • Hospital Epidemiology

    Background:

    • Bloodstream infections (bacteremia) are a significant cause of morbidity and mortality.
    • Polymicrobial bacteremia, involving multiple microorganisms, presents unique diagnostic and therapeutic challenges.
    • Understanding the spectrum of pathogens and associated conditions is crucial for effective management.

    Purpose of the Study:

    • To analyze the incidence, causative agents, and clinical outcomes of polymicrobial bacteremia.
    • To identify common underlying conditions associated with polymicrobial bacteremia.
    • To evaluate the impact of antimicrobial therapy on patient survival.

    Main Methods:

    • Retrospective analysis of 26,961 blood cultures collected over 18 months.

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  • Identification and characterization of isolated microorganisms.
  • Correlation of bacteremia with patient demographics, underlying diseases, and treatment outcomes.

    • Main Results:

    • 1,715 (6%) blood cultures were positive, with 94 cases of polymicrobial bacteremia.
    • Aerobic and anaerobic streptococci were most common, but diverse combinations including Staphylococcus aureus and Klebsiella-Enterobacter-Serratia were observed.
    • Common underlying conditions included neurological illness, malignant neoplasms, burns, and decubitus ulcers.
    • Overall mortality was 54%, with 58% of deaths specifically linked to polymicrobial bacteremia.

    Conclusions:

    • Polymicrobial bacteremia is associated with significant mortality.
    • Underlying disease significantly influences the microbial profile of bacteremia.
    • Timely and appropriate antimicrobial therapy is a critical determinant of patient survival.