Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

492
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
492
Cancer Prevention02:59

Cancer Prevention

6.0K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
6.0K
Stress Prevention and Stress Management Techniques IV01:26

Stress Prevention and Stress Management Techniques IV

23
Stress often leads to unhealthy habits like smoking, excessive drinking, and overeating, which offer short-term relief but ultimately increase long-term health risks. These behaviors create a cycle that temporarily lowers stress levels but can result in severe long-term health consequences. Breaking these habits is essential to reduce the risk of chronic diseases and improve overall well-being. Three primary changes that support better health include quitting smoking, reducing alcohol intake,...
23
Menopause01:28

Menopause

112
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
112
Obesity01:24

Obesity

357
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
357

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comment on Wagner et al. Beyond Glucose-Rethinking Prediabetes for Precision Prevention.

Diabetes care·2026
Same author

Preconception Weight Loss to Prevent Childhood Obesity: Current Evidence and Research Gaps.

Current obesity reports·2026
Same author

No Effect of Prepregnancy Weight Loss Intervention on Child Weight up to Age 5.

Childhood obesity (Print)·2026
Same author

Greater adherence to healthful dietary patterns is associated with lower insomnia risk in the Women's Health Initiative Observational Study.

Sleep·2025
Same author

Development and Validation of Body Mass Index-Specific Waist Circumference Thresholds in Postmenopausal Women : A Prospective Cohort Study.

Annals of internal medicine·2025
Same author

Role of 2-hour plasma glucose in assessing pre-diabetes risk: insights from the vitamin D and type 2 diabetes (D2d) study cohort.

BMJ open diabetes research & care·2025

Related Experiment Video

Updated: May 24, 2025

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.1K

Intentional Weight Loss, Waist Circumference Reduction, and Mortality Risk Among Postmenopausal Women.

Michael Hendryx1, JoAnn E Manson2, Robert J Ostfeld3

  • 1School of Public Health, Indiana University Bloomington.

JAMA Network Open
|March 6, 2025
PubMed
Summary

Intentional weight loss combined with waist circumference reduction in women is linked to lower mortality from all causes, cancer, and cardiovascular disease. Unintentional weight loss increases mortality risk.

More Related Videos

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

10.3K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

771

Related Experiment Videos

Last Updated: May 24, 2025

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause
06:18

An In Vivo Estrogen Deficiency Mouse Model for Screening Exogenous Estrogen Treatments of Cardiovascular Dysfunction After Menopause

Published on: August 13, 2019

12.1K
Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos
13:35

Segmentation and Linear Measurement for Body Composition Analysis using Slice-O-Matic and Horos

Published on: March 21, 2021

10.3K
Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome
06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

771

Area of Science:

  • Gerontology and epidemiology
  • Cardiovascular health and oncology research
  • Public health and preventative medicine

Background:

  • Weight loss research often overlooks intentionality and relies on Body Mass Index (BMI), potentially misinterpreting health risks.
  • Differentiating intentional versus unintentional weight loss is crucial for understanding mortality associations.

Purpose of the Study:

  • To investigate the relationship between intentional weight loss, waist circumference (WC) reduction, and mortality risk.
  • To assess if intentional weight loss, measured by self-report and WC changes, impacts all-cause, cancer, and cardiovascular mortality.

Main Methods:

  • A prospective cohort study of 58,961 women (aged 50-79) from the Women's Health Initiative Observational Study.
  • Follow-up averaged 18.6 years, analyzing weight loss and WC changes from baseline to year 3.
  • Cox proportional hazards regression models assessed associations between weight loss, WC reduction, and mortality outcomes.

Main Results:

  • Intentional weight loss (≥5 lbs) was associated with lower all-cause, cancer, and cardiovascular mortality.
  • Intentional weight loss combined with measured WC reduction showed significant reductions in all-cause, cancer, and cardiovascular mortality.
  • Unintentional weight loss or WC loss, and any weight or WC gain, were linked to increased mortality risk.

Conclusions:

  • Intentional weight loss, particularly when accompanied by reduced waist circumference, is associated with decreased mortality.
  • Strategies promoting intentional weight loss and reduction of central adiposity through diet and exercise are recommended for improved health outcomes.