Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

150
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
150
CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

115
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
115
Altered States of Awareness01:06

Altered States of Awareness

145
Altered states of consciousness represent significant deviations from one's normal mental state. These deviations can range from subtle changes in awareness to profound transformations in perception, thought processes, and sensory experiences. Altered states of consciousness can be triggered by various factors, including drug use, meditation, hypnosis, illness, or even intense fatigue.
The ingestion of substances like stimulants or hallucinogens leads to chemical alterations in the brain...
145
Drug Therapy01:28

Drug Therapy

34
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
34
Blind Procedures02:07

Blind Procedures

10.6K
Ideally, the people who observe and record the children’s behavior are unaware of who was assigned to the experimental or control group, in order to control for experimenter bias. Experimenter bias refers to the possibility that a researcher’s expectations might skew the results of the study. Remember, conducting an experiment requires a lot of planning, and the people involved in the research project have a vested interest in supporting their hypotheses. If the observers knew which...
10.6K
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

101
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
101

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

U.S. study of Scandinavian prison model expands.

Science (New York, N.Y.)·2025
Same author

A new 'mini-CRISPR' flexes its editing power in monkey muscles.

Science (New York, N.Y.)·2025
Same author

Runners-up.

Science (New York, N.Y.)·2024
Same author

Storm warnings for FDA and CDC.

Science (New York, N.Y.)·2024
Same author

Preprint on Alzheimer's drug deaths ignites author dispute.

Science (New York, N.Y.)·2024
Same author

The counterattack.

Science (New York, N.Y.)·2024

Related Experiment Video

Updated: May 24, 2025

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
07:30

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

6.4K

Psychedelic trials face downsides of the 'trip'.

Jennifer Couzin-Frankel

    Science (New York, N.Y.)
    |March 6, 2025
    PubMed
    Summary

    New research seeks to distinguish between participant expectations and actual drug effects. This helps clarify the true impact of medications in clinical trials.

    Area of Science:

    • Pharmacology
    • Clinical Psychology

    Background:

    • Participant expectations can influence perceived treatment outcomes.
    • Differentiating subjective expectations from objective drug effects is crucial for rigorous clinical research.

    More Related Videos

    Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
    12:00

    Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

    Published on: November 19, 2014

    12.8K
    Performing Behavioral Tasks in Subjects with Intracranial Electrodes
    12:10

    Performing Behavioral Tasks in Subjects with Intracranial Electrodes

    Published on: October 2, 2014

    11.3K

    Related Experiment Videos

    Last Updated: May 24, 2025

    Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
    07:30

    Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

    Published on: August 18, 2020

    6.4K
    Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization
    12:00

    Investigating the Effects of Antipsychotics and Schizotypy on the N400 Using Event-Related Potentials and Semantic Categorization

    Published on: November 19, 2014

    12.8K
    Performing Behavioral Tasks in Subjects with Intracranial Electrodes
    12:10

    Performing Behavioral Tasks in Subjects with Intracranial Electrodes

    Published on: October 2, 2014

    11.3K