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Prevalence of Latent Tuberculosis Infection in Multiple Sclerosis Patients from an Endemic Country: A Cross-Sectional
Simón Cárdenas-Robledo1, Juan Camilo Carrillo-Martinez2, María Isabel Zuluaga3
1Centro de Esclerosis Múltiple (CEMHUN), Hospital Universitario Nacional de Colombia, Bogotá, Colombia; Departamento de Medicina Interna, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia.
Background:
MS patients are at increased risk for tuberculosis reactivation due to immunosuppressive therapies. Prevalence of latent tuberculosis in MS from our country is unknown.
Objective:
To assess the prevalence and determinants of latent tuberculosis infection (LTBI) in MS patients from Colombia.
Methods:
Multicentric, cross-sectional, retrospective study involving confirmed MS patients. LTBI was defined as a positive tuberculin skin test in asymptomatic patients with normal chest imaging. The prevalence (95 %CI) of LTBI was estimated and compared to the general prevalence with a one-sample proportion test. Determinants of LTBI were analysed using adjusted logistic regression.
Results:
481 patients were included, with a mean age of 42 years and a mean MS duration of 10 years. The prevalence of LTBI was 6.24 % (95 %CI: 4.25-8.78), significantly lower than that of the general population (21.11 %; p < 0.001). Male sex (OR: 2.52; 95 %CI: 1.00-6.28, p = 0.046) was independently associated with LTBI.
Conclusion:
LTBI is significantly less prevalent among our sample compared to the general population, and is associated with male sex.
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