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Ginseng in delaying brain aging: Progress and Perspectives.

Jingwen Niu¹, Guoqi Zhu¹, Junjie Zhang¹

¹Center for Xin'an Medicine and Modernization of Traditional Chinese Medicine of IHM, and Key Laboratory of Molecular Biology (Brain diseases), Anhui University of Chinese Medicine, Hefei 230012, China; Key Laboratory of Xin'an Medicine, the Ministry of Education, Anhui University of Chinese Medicine, Hefei 230038, China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology

|March 6, 2025

Summary

Ginseng shows promise in delaying brain aging and managing related diseases. Its bioactive compounds support neural homeostasis with minimal side effects, offering potential for neuroprotection.

Keywords:

Active components Brain aging Ginseng Intracellular homeostasis Neurodegenerative diseases

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Area of Science:

Neuroscience
Pharmacology
Gerontology

Background:

The Shennong Bencao Jing notes ginseng's life-prolonging properties.
Ginseng is recognized for neuroprotective effects against brain aging.
A comprehensive review on ginseng's impact on brain aging is needed.

Purpose of the Study:

To review ginseng's role in delaying brain aging.
To identify bioactive constituents, mechanisms, and side effects.
To support ginseng's use in senescence and aging-related diseases.

Main Methods:

Literature review of human studies from 2017-present.
Databases searched: PubMed, Web of Science.
Keywords: Ginseng, Brain aging, CNS, homeostasis, peripheral system.

Main Results:

Ginseng contains diverse bioactive compounds (ginsenosides, polysaccharides, etc.).
Ginseng may maintain neural homeostasis via central and peripheral actions.
Potential toxic side effects of ginseng are minimal.

Conclusions:

Ginseng and its constituents show promise for delaying brain aging.
Further research needed on ginseng's drug-target-efficacy relationships.
Facilitating clinical translation for neurodegenerative diseases.