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Published on: March 29, 2017
Fighting off a gut feeling: A gut-brain-lung neuroimmune circuit
1Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA; Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Allen Discovery Center for Neuroimmune Interactions, Icahn School of Medicine at Mount Sinai, New York, NY 10019, USA.
Abstract:
In this issue of Neuron, Chen et al. identify a postprandial neuroimmune axis by which feeding-induced stimulation of the gastrointestinal tract triggers type 2 immunity in the lung.1 This study hints that there are likely distinct sensory and motor circuits coordinated by the brain across different tissues to drive neuroinflammation.
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