The halo of future bio-industry based on engineering Halomonas

The utilization of microorganisms to transform biomass into biofuels and biochemicals presents a viable and competitive alternative to conventional petroleum refining processes. Halomonas species are salt-tolerant and alkaliphilic, endowed with various beneficial properties rendering them as contamination resistant platforms for industrial biotechnology, facilitating the commercial-scale production of valuable bioproducts. Here we summarized the metabolic and genomic engineering approaches, as well as the biochemical products synthesized by Halomonas. Methods were presented for expanding substrates utilization in Halomonas to enhance its capabilities as a robust workhorse for bioproducts. In addition, we briefly reviewed the Next Generation Industrial Biotechnology (NGIB) based on Halomonas for open and continuous fermentation. In particular, we proposed the industrial attempts from Halomonas chassis and the rising prospects and essential strategies to enable the successful development of Halomonas as microbial NGIB manufacturing platforms.