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Sinopharm COVID-19 Vaccination during Pregnancy Triggers Thyroid Stimulating Hormone Levels in Newborns

Aylar Vatanparast1, Faeze Daghigh2, Hossein Akbari3

  • 1Infectious Diseases Research Center, Tabriz Medical Sciences, Islamic Azad University, Tabriz, Iran.

American Journal of Perinatology
|March 6, 2025
PubMed

Insights

COVID-19 vaccination in pregnant women using Sinopharm/BBIBP-CorV was evaluated for its effects on neonatal thyroid function. The study found a slight, clinically insignificant increase in thyroid-stimulating hormone (TSH) levels in newborns.

Area of Science:

  • Endocrinology
  • Immunology
  • Obstetrics

Background:

  • Pregnant women are a unique demographic for COVID-19 vaccination due to potential effects on the fetus and placenta.
  • COVID-19 vaccines have been linked to endocrine complications, including thyroid disease.

Purpose of the Study:

  • To investigate the impact of Sinopharm/BBIBP-CorV vaccination during or before pregnancy on neonatal thyroid-stimulating hormone (TSH) levels.
  • To assess potential endocrine disruption in newborns following maternal COVID-19 vaccination.

Main Methods:

  • A study involving pregnant women divided into three groups: unvaccinated, vaccinated during pregnancy, and vaccinated before pregnancy.
  • Measurement of neonatal TSH levels in infants aged 3-5 days using blood samples.
  • Comparison of mean TSH levels across the study groups.

Main Results:

  • Maternal Sinopharm/BBIBP-CorV vaccination during or before pregnancy was associated with a slight increase in mean neonatal TSH levels.
  • The observed increase in neonatal TSH was not statistically significant and considered clinically insignificant.
  • No significant endocrine disruption was detected.

Conclusions:

  • Sinopharm/BBIBP-CorV vaccination during or prior to pregnancy does not lead to clinically significant alterations in neonatal TSH levels.
  • The study suggests that COVID-19 vaccination with Sinopharm/BBIBP-CorV is safe concerning neonatal thyroid function.
  • Further research may explore long-term effects and other vaccine types.

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