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Updated: May 5, 2026

Methods for Acute and Subacute Murine Hindlimb Ischemia
Published on: June 21, 2016
Acute Limb Ischemia Interventions
Asmaa Ahmed1, Nauman Naeem1, Aakriti Jain1
1Department of Internal Medicine, Rochester General Hospital, 1425 Portland Avenue, Rochester, NY 14621, USA.
Abstract:
Acute limb ischemia (ALI) is characterized by a sudden decrease in limb perfusion that threatens the viability of the limb. ALI can result from various causes including arterial embolism, thrombosis, or trauma. The diagnosis is predominantly clinical, guided by the "6 Ps" mnemonic-pain, pallor, pulse deficit, paralysis, paresthesia, and poikilothermia-and confirmed through imaging modalities if needed. Treatment decisions are informed by the Rutherford classification, ranging from viable to irreversibly damaged limbs. Early diagnosis and timely intervention are critical for improving limb salvage and reducing amputation rates.
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