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Posture and theophylline kinetics.

J B Warren, F Cuss, P J Barnes

    British Journal of Clinical Pharmacology
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Posture significantly impacts theophylline absorption. Standing increased plasma theophylline levels compared to lying down, suggesting posture influences drug kinetics.

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    Area of Science:

    • Pharmacokinetics
    • Human Physiology

    Background:

    • Theophylline is a medication used to treat respiratory diseases.
    • Diurnal variations in drug absorption and metabolism are common.
    • Posture's influence on drug kinetics is not fully understood.

    Purpose of the Study:

    • To investigate the effect of posture on theophylline pharmacokinetics.
    • To determine if posture contributes to diurnal variations in theophylline levels.

    Main Methods:

    • Six healthy male participants ingested 450 mg of slow-release aminophylline.
    • Plasma theophylline concentrations were measured hourly for 6 hours.
    • Participants maintained either a standing or supine posture throughout the study period.

    Main Results:

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    • Mean theophylline plasma levels were significantly higher in the standing position compared to the supine position at all measured time points (P < 0.01).
    • This indicates a faster or more complete absorption of theophylline when standing.

    Conclusions:

    • Posture significantly affects theophylline absorption and plasma concentrations.
    • Postural variations may explain, in part, the observed diurnal variations in theophylline kinetics.
    • Clinical recommendations for theophylline administration should consider patient posture.