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Updated: May 23, 2025
Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Rhodium(I)-Catalyzed Asymmetric Cascade Reactions
Yu-Chu Yang1, Wei-Sian Li1, Hsyueh-Liang Wu1
1Department of Chemistry, National Taiwan Normal University, No.88, Sec. 4, Tingzhou Rd., Taipei, 11677, Taiwan.
Abstract:
Rhodium(I)-catalyzed asymmetric cascade reactions have emerged as powerful tools in contemporary organic synthesis, enabling efficient construction of complex molecular architectures. These transformations proceed through organorhodium intermediates, which undergo additions to reactive π-bonds, subsequently triggering cascade reactions with neighboring functional groups to effectively forge multiple carbon-carbon bonds and stereogenic centers in a single step under mild conditions. This article reviews the pioneering developments and recent breakthroughs from 2002 to 2024, highlighting the attractive advantages of rhodium(I)-catalyzed asymmetric cascade reactions and their profound impacts on synthetic organic chemistry.
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