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Published on: June 7, 2015
In Situ-Gelling Antimicrobial Poly(oligoethylene glycol methacrylate)-Based Hydrogels Integrating Bound Quaternary
Fei Xu1, Evelyn Cudmore1, Sadru-Dean Walji1
1Department of Biomedical Engineering, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4L8, Canada.
Abstract:
In situ-gelling antibacterial hydrogels are reported in which two antibacterial entities (quaternary ammonium (QA) groups and the antibiotic ciprofloxacin (CIP)) are tethered to a single precursor based on the anti-fouling polymer poly(oligoethylene glycol methacrylate) (POEGMA). Synergism between the QA and CIP tethers is demonstrated to enable broad-spectrum killing and/or disinfection of both gram-positive and gram-negative bacteria both in vitro and in vivo while also supporting improved functional recovery of uninjured skin morphology. Coupled with the suitable mechanics, swelling capacity, and stability of the gels, the multi-mechanism antibacterial properties of the hydrogels offer promise for treating or preventing infections of burn wounds.
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