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Association between hyperuricemia and all-cause mortality in people taken Statins: a retrospective cohort study

Bin Zhu1, Zijun He2, Mingfen Wu1

  • 1Department of Pharmacy, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Frontiers in Pharmacology
|March 7, 2025
PubMed

Insights

High uric acid levels (hyperuricemia) increase the risk of death in patients taking statins, even though statins can lower uric acid. Individuals with hyperuricemia on statin therapy require careful monitoring of their serum uric acid levels.

Area of Science:

  • Cardiovascular Medicine
  • Pharmacology
  • Nephrology

Background:

  • Statins are widely prescribed for cardiovascular health.
  • Statins have demonstrated benefits in reducing serum uric acid levels.
  • Hyperuricemia is a condition of elevated uric acid in the blood.

Purpose of the Study:

  • To investigate the association between hyperuricemia and all-cause mortality in individuals using statins.
  • To determine if elevated serum uric acid levels impact mortality risk in statin users.

Main Methods:

  • Retrospective cohort study utilizing the National Health and Nutrition Examination Survey (NHANES) database (2005-2018).
  • Weighted Cox proportional hazards models were employed to analyze the relationship between hyperuricemia and all-cause mortality.
  • Analysis included 1,958 participants, with 529 diagnosed with hyperuricemia.

Main Results:

  • Hyperuricemia was significantly correlated with increased all-cause mortality among statin users (HR = 1.13, 95% CI: 1.02-1.24, p = 0.0161) after adjusting for confounders.
  • Participants with hyperuricemia had a significantly higher risk of all-cause mortality compared to those with normal uric acid levels (HR = 1.51, 95% CI: 1.16-1.96, P = 0.0023).
  • A higher proportion of participants in the hyperuricemia group (42.05%) took more than five medications compared to the non-hyperuricemia group (32.49%).

Conclusions:

  • Despite statins' potential to lower uric acid, hyperuricemia remains a significant risk factor for all-cause mortality in statin users.
  • Individuals on statin therapy with hyperuricemia should closely monitor their serum uric acid (SUA) levels.
  • This highlights the importance of managing hyperuricemia in patients prescribed statins.
Abstract

Keywords:
National Health and Nutrition Examination SurveyStatin (HMG-CoA reductase inhibitor)all-cause mortalityhyperuricemiaserum uric acid

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