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Circulating hyaluronate in psoriasis
The British Journal of Dermatology
|June 1, 1985
Summary
Serum hyaluronate levels are significantly elevated in patients with psoriasis, particularly those with active skin or joint disease. This finding suggests dermal and synovial tissue involvement in psoriasis pathogenesis.
Area of Science:
- Biochemistry
- Dermatology
- Rheumatology
Background:
- Psoriasis is a chronic inflammatory skin condition.
- Elevated serum hyaluronate may indicate tissue damage or inflammation.
Purpose of the Study:
- To measure serum hyaluronate concentrations in patients with psoriasis.
- To investigate the correlation between serum hyaluronate levels and disease activity.
Main Methods:
- Radioassay was used to measure serum hyaluronate levels in 44 psoriasis patients.
- Serum hyaluronate was compared between patients with skin lesions only and those with skin lesions and arthropathy.
- Blister fluid hyaluronate was analyzed in two patients.
Main Results:
- Significantly elevated serum hyaluronate was found in both patient groups.
- Highest levels correlated with widespread active skin disease and/or active arthritis.
- Normal hyaluronate levels were observed in atopic dermatitis patients.
Conclusions:
- Increased serum hyaluronate in psoriasis suggests dermal and synovial tissue involvement.
- Hyaluronate levels may serve as a marker for disease activity and inflammation.